研究

1. 研究の流れ

開学当初、初代検査部教授(のち関西医科大学内科教授) 故・安永幸二郎先生のご指導のもと、血小板機能を中心に研究がスタートしました。臨床的には、その当時本邦で初めてDICにfuthamが有効であることを報告しています。血小板研究は、さらに血小板系造血の機序解明へと発展し、特に血小板系造血への種々のサイトカインの影響や骨髄ストローマ細胞との協調作用などを研究しています。また、京都府立医科大学衛生学教室との共同研究でソースの異なる幹細胞の特性を、京都大学輸血部との共同研究でビスフォスフォネートの抗白血病作用の研究を行っています。

2. 主要研究テーマ

巨核球系造血の機序
新しい抗白血病薬の開発

3. 学会活動

日本血液学会
日本臨床血液学会
日本造血幹細胞移植学会
日本血栓止血学会
日本輸血学会
日本癌学会
日本化学療法学会
International Society of Thrombosis and Haemostasis
American Society of Hematology

4.研究業績(2021年度以降)

  1. Miyake Y, Tanaka K, Nagata C, Furukawa S, Andoh A, Yokoyama T, Yoshimura N, Mori K, Ninomiya T, Yamamoto Y, Takeshita E, Ikeda Y, Saito M, Ohashi K, Imaeda H, Kakimoto K, Higuchi K, Nunoi H, Mizukami Y, Suzuki S, Hiraoka S, Okada H, Kawasaki K, Higashiyama M, Hokari R, Miura H, Miyake T, Kumagi T, Kato H, Hato N, Sayama K, Hiasa Y; Japan Ulcerative Colitis Study Group. IL12B rs6887695 polymorphism and interaction with alcohol intake in the risk of ulcerative colitis in Japan. Cytokine. 2022 May 11;155:155901. doi:10.1016/j.cyto.2022.155901.
     
  2. Hirayama H, Morita Y, Imai T, Takahashi K, Yoshida A, Bamba S, Inatomi O, Andoh A. Ustekinumab trough levels predicting laboratory and endoscopic remission in patients with Crohn’s disease. BMC Gastroenterol. 2022 Apr 21;22(1):195. doi: 10.1186/s12876-022-02271-4.
  3. Mori N, Hongo M, Takemura S, Sugitani Y, Nakamura F, Tani M, Nishida A, Inatomi O, Andoh A, Ban H. Mixed neuroendocrine-non-neuroendocrine neoplasm associated with autoimmune gastritis. Clin Case Rep. 2022 Mar 22;10(3):e05640. doi: 10.1002/ccr3.5640.
  4. Okabayashi S, Yamazaki H, Tominaga K, Miura M, Sagami S, Matsuoka K, Yamaguchi Y, Noake T, Ozeki K, Miyazaki R, Kamano T, Fukuda T, Yoshioka K, Ando K, Fukuzawa M, Andoh A, Yamamoto Y, Hibi T, Kobayashi T; IBD Terakoya Group. Lower effectiveness of intravenous steroid treatment for moderate-to-severe ulcerative colitis in hospitalised patients with older onset: A multicenter cohort study. Aliment Pharmacol Ther. 2022 Mar 11. doi: 10.1111/apt.16865.
  5. Shintani S, Inatomi O, Takeda Y, Fujimoto T, Bamba S, Kutsumi H, Andoh A. A case of massive bleeding after endoscopic sphincterotomy in a patient with a history of large walled-off pancreatic necrosis in the area of the pancreatic groove. Endoscopy. 2022 Feb 28. doi: 10.1055/a-1769-4531.
  6. Shintani S, Inatomi O, Bamba S, Takeda Y, Fujimoto T, Ota S, Tsuji Y, Kutsumi H, Watanabe Y, Andoh A. Larger Volume and Higher Fat Content of the Pancreatic Head Are Predictive Factors for Postendoscopic Retrograde Cholangiopancreatography Pancreatitis. Pancreas. 2022 Jan 1;51(1):28-34. doi: 10.1097/MPA.0000000000001957.
  7. Nishimura K, Fujita Y, Ida S, Yanagimachi T, Ohashi N, Nishi K, Nishida A, Iwasaki Y, Morino K, Ugi S, Nishi E, Andoh A, Maegawa H. Glycaemia and body weight are regulated by sodium-glucose cotransporter 1 (SGLT1) expression via O-GlcNAcylation in the intestine. Mol Metab. 2022 Feb 19:101458. doi: 10.1016/j.molmet.2022.101458.
  8. Chatani S, Seki K, Sonoda A, Murakami Y, Tomozawa Y, Fujimoto T, Andoh A, Watanabe Y. Bleeding anorectal varices treated by a direct puncture approach through the greater sciatic foramen: The utility of a steerable microcatheter for reverse catheterization. Radiol Case Rep. 2022 Feb 3;17(4):1104-1109. doi: 10.1016/j.radcr.2022.01.051.
  9. Yamashita N, Imai T, Kawahara M, Inatomi O, Andoh A. Low immunogenicity of vedolizumab determined by a simple drug-tolerant assay in patients with ulcerative colitis. J Clin Biochem Nutr. 2022 Jan;70(1):72-78. doi: 10.3164/jcbn.21-98. Epub 2021 Oct 2.
  10. Ohno M, Imai T, Chatani M, Nishida A, Inatomi O, Kawahara M, Hoshino T, Andoh A. The anti-inflammatory and protective role of interleukin-38 in inflammatory bowel disease. J Clin Biochem Nutr. 2022 Jan;70(1):64-71. doi: 10.3164/jcbn.21-104. Epub 2021 Nov 5.
  11. Nishikawa A, Tanaka K, Miyake Y, Nagata C, Furukawa S, Andoh A, Yokoyama T, Yoshimura N, Mori K, Ninomiya T, Yamamoto Y, Takeshita E, Ikeda Y, Saito M, Ohashi K, Imaeda H, Kakimoto K, Higuchi K, Nunoi H, Mizukami Y, Suzuki S, Hiraoka S, Okada H, Kawasaki K, Higashiyama M, Hokari R, Miura H, Miyake T, Kumagi T, Kato H, Hato N, Sayama K, Hiasa Y; Japan Ulcerative Colitis Study Group. Active and passive smoking and risk of ulcerative colitis: A case-control study in Japan. J Gastroenterol Hepatol. 2021 Nov 29. doi: 10.1111/jgh.15745.
  12. Kakuta Y, Iwaki H, Umeno J, Kawai Y, Kawahara M, Takagawa T, Shimoyama Y, Naito T, Moroi R, Kuroha M, Shiga H, Watanabe K, Nakamura S, Nakase H, Sasaki M, Hanai H, Fuyuno Y, Hirano A, Matsumoto T, Kudo H, Minegishi N, Nakamura M, Hisamatsu T, Andoh A, Nagasaki M, Tokunaga K, Kinouchi Y; MENDEL study group, Masamune A. Crohn’s disease and early exposure to thiopurines are independent risk factors for mosaic chromosomal alterations in patients with inflammatory bowel diseases. J Crohns Colitis. 2021 Nov 9:jjab199. doi: 10.1093/ecco-jcc/jjab199.
  13. Fukumoto Y, Kobayashi Y, Takemura S, Maeda K, Nakamura F, Inatomi O, Andoh A, Ban H. A case of appendix adenocarcinoma associated with ulcerative colitis. Clin Case Rep. 2021 Aug 30;9(9):e04768. doi: 10.1002/ccr3.4768.
  14. Andoh A, Kawahara M, Imai T, Tatsumi G, Inatomi O, Kakuta Y. Thiopurine pharmacogenomics and pregnancy in inflammatory bowel disease. J Gastroenterol. 2021 Oct;56(10):881-890. doi: 10.1007/s00535-021-01805-z. Epub 2021 Jul 21.
  15. Miyake Y, Tanaka K, Nagata C, Furukawa S, Andoh A, Yokoyama T, Yoshimura N, Mori K, Ninomiya T, Yamamoto Y, Takeshita E, Ikeda Y, Saito M, Ohashi K, Imaeda H, Kakimoto K, Higuchi K, Nunoi H, Mizukami Y, Suzuki S, Hiraoka S, Okada H, Kawasaki K, Higashiyama M, Hokari R, Miura H, Miyake T, Kumagi T, Kato H, Hato N, Sayama K, Hiasa Y; Japan Ulcerative Colitis Study Group. Dietary intake of vegetables, fruit, and antioxidants and risk of ulcerative colitis: A case-control study in Japan. Nutrition. 2021 Nov-Dec;91-92:111378. doi: 10.1016/j.nut.2021.111378. Epub 2021 Jun 2. PMID: 34265581.
  16. Miyake T, Mori H, Yasukawa D, Hexun Z, Maehira H, Ueki T, Kojima M, Kaida S, Iida H, Shimizu T, Ohno M, Andoh A, Tani M. The Comparison of Fecal Microbiota in Left-Side and Right-Side Human Colorectal Cancer. Eur Surg Res. 2021;62(4):248-254. doi: 10.1159/000516922.
  17. Yokota Y, Inatomi O, Nakagawa M, Kakuda K, Hiroe K, Sakai S, Osaki R, Iwasa M, Kawahara M, Kito K, Andoh A, Bamba H. Acquired Coagulation Factor V Inhibitor That Was Successfully Treated with Oral Corticosteroid Therapy. Intern Med. 2021 Aug 15;60(16):2663-2666. doi: 10.2169/internalmedicine.7453-21. Epub 2021 Jun 12.
  18. Ban H, Inatomi O, Murata M, Otsuka T, Oi M, Matsumoto H, Bamba S, Andoh A. Vonoprazan vs lansoprazole for the treatment of artificial gastric ulcer after endoscopic submucosal dissection: a prospective randomized comparative study. J Clin Biochem Nutr. 2021 May;68(3):259-263. doi: 10.3164/jcbn.20-143. Epub 2020 Dec 3.
  19. Bamba S, Inatomi O, Nishida A, Ohno M, Imai T, Takahashi K, Naito Y, Iwamoto J, Honda A, Inohara N, Andoh A. Relationship between the gut microbiota and bile acid composition in the ileal mucosa of Crohn’s disease. Intest Res. 2021 May 14. doi: 10.5217/ir.2021.00054. Epub ahead of print.
  20. Noda S, Iida H, Fujimoto T, Wakasugi Y, Yabuta N, Sudou M, Hira D, Tani M, Andoh A, Morita SY, Terada T. Exploratory analysis of target concentration of lenvatinib in the treatment of hepatocellular carcinoma. Cancer Chemother Pharmacol. 2021 Aug;88(2):281-288. doi: 10.1007/s00280-021-04286-2. Epub 2021 Apr 29.

※以前の研究業績はお知らせに投稿する等で対応します。

ページトップに戻る